Fig. 2.

Detailed SNV profile of R0-resected PDAC patients. (a) Lollipop plot of four most commonly mutated genes. The most common SNVs are annotated for each gene. Modified from cbioportal [38,39]. (b) Overview of the different KRAS mutations with respect to their affected codon position and resulting amino acid change. The number of mutations for each variant is annotated. (c) Comparison of mutation frequencies and type with findings from Bailey et al. [6]. The 20 most frequently altered genes are shown in order of mutation frequency, based on the CONKO-005 cohort results. Mutations types are indicated by color. Abbreviations: TAD = trans-activation domain, RD = regulatory domain.