Appendix Table 2.
A list of some common human NK cell receptors and their corresponding ligands.
| Receptor | Ligand |
|---|---|
| Non-HLA-specific receptors | |
| Co-receptors | |
| CD59 | LFA-2 (CD2) |
| NTB-A (CD352) | NTB-A (CD352) |
| NKp80 | AICL (activation-induced C-type lectin) |
| DNAM-1 (226) | Nectin-2 (CD112), PVR (CD155) |
| 2B4 (244) | CD48 |
| Activating | |
| NKp30 (CD337) | B7-H6, BAG6/BAT3, HCMV-pp65, heparin sulfate |
| NKp44 (CD336) | 21spe-MLL5-Nidogen-1, viral HA, proliferating nuclear cell Ag (PCNA) |
| NKp46 (CD335) | CFP (complement factor P)/properdin, viral HA and HN, PfEMP1, heparin sulfate |
| NKG2D (CD314) | MIC-A, MIC-B, ULBP 1-6 |
| FcγRIII (CD16) | IgG |
| Inhibitory | |
| PD-1 (CD279) | PD-L1 (CD274), PD-L2 (CD273) |
| Siglec-7 (CD328) | Ganglioside DSGb5 |
| IRP60 (CD300a) | Phosphatidylethanolamine, phosphatidylserine, Pseudorabide virus, α-Herpesvirus |
| Tactile (CD96) | PVR (CCD155) |
| IL1R8 | IL-37 |
| TIGIT | PVR (CD155) |
| TIM-3 | Gal-9, PtdSer, HMGB1, CEACAM1 |
| HLA-specific receptors | |
| Activating | |
| KIR2DS1 | HLA-C2 |
| KIR2DS2/3 | unknown |
| KIR2DL4 | HLA-G |
| KIR2DS4 | HLA-A*11 and some HLA-C |
| KIR2DS5 | HLA-C2 (variable) |
| KIR3DS1 | HLA-Bw4, HLA-F |
| NKG2C | HLA-E |
| Inhibitory | |
| NKG2A | HLA-E |
| KIR2DL1 | HLA-C2 |
| KIR2DL2/3 | HLA-C1, HLA-C2, few HLA-Bb |
| KIR2DL5 | unknown |
| KIR3DL1 | HLA-A-Bw4, HLA-B-Bw4 |
| KIR3DL2 | HLA-A*03, HLA-A*11 |
| ILT2/LIR-1 | Different MHC-I alleles |
| LAG-3 (CD223) | MHC-II |