Fig. 1.

Metabolic profiling and prognostic signature of PDAC patients. (a) Heatmap showing differential metabolic profiles of PDAC samples using unsupervised hierarchical clustering. The column annotation represents the main classes of metabolites. (b) Pie chart indicating the global distribution of metabolic classes in all samples. (c) Waterfall plot showing the sorted scores of patients in the identified metabolic signatures. (d) Kaplan-Meier plot of survival using univariate analysis based on ICA5 scores of patients. Two groups of patients were considered with high and low score. (e) Univariate relative risk for overall survival associated with the metabolic signature. Each point is a patient's relative risk of disease with error bars corresponding to a 95% confidence interval. (f) Barplot illustrating the contribution of the top 100 metabolites into the component ICA5.