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. 2021 Apr 19;9:21. doi: 10.1186/s40635-021-00377-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Portions of lung tissue classified as not aerated, poorly aerated, normally aerated and hyperinflated among P_ETCO₂/PaCO₂ ratio quartiles to the response of step increase of PEEP at 5, 15 and 45 cmH₂O. The asterisk denotes p < 0.001 among the portions of tissue throughout P_ETCO₂/PaCO₂ ratio quartiles for Mann–Whitney test. The dollar denotes p < 0.001 among portions of lung tissue to the response to PEEP for Wilcoxon test