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. 2021 Apr 19;18:94. doi: 10.1186/s12974-021-02147-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Human Huntington’s disease PSC-derived microglia are hyper-reactive to an immune challenge. IsoHD PSC-derived microglia were stimulated with 1 μg/ml LPS and 10 ng/ml IFNγ for 24 h and their supernatants assessed by multiplex ELISA for the secretion of inflammation-associated cytokines. In most cases, there was a trend of increased production of the cytokines measured, with statistically significantly elevated levels of the pro-inflammatory cytokines, IL-6 and TNFα. Data are expressed as the fold-change following stimulation normalised to total cell number, presented as mean ± SEM, n = 3, and analysed by one-way ANOVA with Tukey’s post-test, (* p < 0.05)