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. 2021 Apr 19;21:75. doi: 10.1186/s12874-021-01260-7

Fig. 3.

Fig. 3

Graphical comparison of ITT versus PP point estimate. ARR = absolute risk reduction; ITT = intention-to-treat; PP = per protocol. The size of the points on the graph is proportional to the sample size of the ITT population. A diagonal line is drawn at y = x, so ITT analysis is more conservative for points above the line and PP analysis is more conservative for points below the line