Fig. 1.

Suppression of breast tumor growth in Nude mice inoculated with Her2+ human breast cancer cells (BT74) after doxorubicin (5 mg/kg/wk) and trastuzumab (4 mg/kg/wk) treatment. a Tumor volume measured on indicated days for individual mice after tumor cell inoculation with weekly doxorubicin/trastuzumab treatment initiated when tumor volume reached 100 mm3. b Average body weight of tumor-bearing mice treated with 5 mg/kg doxorubicin/4 mg/kg trastuzumab (treated; n = 4) and mice without tumors (untreated; n = 5) were given PBS. Mice in these experiments followed Study design II (see Table 1 in Methods)