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. 2021 Apr 19;7:15. doi: 10.1186/s40959-021-00100-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Echocardiography of Treated vs Untreated Hearts. Mice in these studies were treated in study design I and study design II (see Table 1 in Methods section). LVIDd, left ventricular internal diameter end diastole; LVIDs, left ventricular internal diameter end systole; LVPWd, left ventricular posterior wall thickness, end diastole; LVPWs, left ventricular posterior wall thickness, end systole; IVSd, interventricular septal end diastole; IVSs, interventricular septal end systole; Heart Mass, direct measure; FS, fractional shortening; EF, ejection fraction; E/E’, ratio of mitral peak velocity of filling (E) to early diastolic mitral annular velocity (E’); Longitudinal Strain, long axis longitudinal strain (shortening); Radial Strain, long axis radial strain (thickening); Circumferential Strain, short axis circumferential strain (shortening); *p < 0.05