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. 2021 Apr 19;19:157. doi: 10.1186/s12967-021-02823-4

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© The Author(s) 2021, corrected publication 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — PFD attenuated the severity of synovial fibrosis (P < 0.01). Masson’s trichrome staining (a: scale bar-500 μm) and immunofluorescence staining (b: scale bar-200 μm) demonstrated that collagen deposition increased significantly in the 4-week and 12-week groups, while collagen deposition was lower in the PFD group. Quantification of collagen volume fraction (c) and mean fluorescence intensity (d) established that PFD reduced fibrosis in the synovium. Data represented means ± SD. *P < 0.05, **P < 0.01, ***P < 0.001 (the 4-week and 12-week groups were compared with the control group; the PFD group was compared with the control and 12-week groups) (unpaired t-test)