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. 2021 Apr 19;19:157. doi: 10.1186/s12967-021-02823-4

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© The Author(s) 2021, corrected publication 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — PFD reduced inflammation of the synovium. H&E staining of the synovium in different groups (a: scale bar of top row-1 mm; scale bar of bottom row-100 μm) and the corresponding synovitis scores (b). Black arrows indicate the lining of the synovium. In the control group, the lining was just 1–2 cells thick without hypertrophy or hyperplasia. Synoviocyte hypertrophy and hyperplasia were observed in the 4 and 12-week groups. Blue arrows indicate vascular proliferation, only observed in the 4 and 12-week groups. Data represent means ± SD. *P < 0.05, **P < 0.01, ***P < 0.001 (the 4 and 12-week groups were compared with the control group; the PFD group was compared with the sham and 12-week groups) (independent-samples t-test)