Table 2.
Association of PACU-OpResc with primary and secondary endpoints
| Outcomes | No PACU-OpResc (n = 743) |
PACU-OpResc (n = 211) |
Unadjusted analysis | Adjusted analysis | ||
|---|---|---|---|---|---|---|
| OR/IRR (95% CI) | p-value | OR/IRR (95% CI) | p-value | |||
| Primary Outcome | ||||||
| PACU length of stay, min | 269 (194, 381) | 286 (221, 427) | 1.21 (1.08, 1.35) | 0.001 | 1.20 (1.07, 1.34) | 0.001 |
| Secondary Outcomes | ||||||
| PACU discharge delay | ||||||
| Any reason, n (%) | 283 (38.09%) | 128 (60.66%) | 2.51 (1.83, 3.43) | < 0.001 | 2.57 (1.83, 3.60) | < 0.001 |
| Pain, n (%) | 90 (12.11%) | 87 (41.23%) | 5.09 (3.58, 7.24) | < 0.001 | 5.15 (3.51, 7.57) | < 0.001 |
| Cardiovascular, n (%) | 125 (16.82%) | 42 (19.91%) | 1.23 (0.83, 1.81) | 0.299 | 1.34 (0.88, 2.04) | 0.175 |
| PONV, n (%) | 5 (0.67%) | 3 (1.42%) | 2.13 (0.50, 8.98) | 0.304 | 1.76 (0.34, 8.96) | 0.498 |
| Sedation/Respiratory, n (%) | 65 (8.75%) | 22 (10.43%) | 1.21 (0.73, 2.02) | 0.455 | 1.01 (0.57, 1.80) | 0.978 |
| Voiding, n (%) | 51 (6.86%) | 23 (10.90%) | 1.66 (0.99, 2.79) | 0.055 | 1.63 (0.93, 2.85) | 0.085 |
| Hypotension MAP < 65 mmHg | ||||||
| Frequency, n (%) | 710 (95.56%) | 201 (95.26%) | 0.93 (0.45, 1.93) | 0.854 | 1.04 (0.47, 2.31) | 0.924 |
| Duration, min | 16 (6, 32) | 14 (6, 28) | 0.84 (0.71, 1.00) | 0.048 | 0.96 (0.82, 1.12) | 0.587 |
| Hypotension MAP < 55 mmHg | ||||||
| Frequency, n (%) | 485 (65.28%) | 128 (60.66%) | 0.82 (0.60, 1.12) | 0.218 | 0.90 (0.64, 1.26) | 0.531 |
| Duration, min | 2 (0, 5) | 1 (0, 5) | 0.85 (0.66, 1.08) | 0.184 | 0.94 (0.74, 1.21) | 0.651 |
Data are expressed as frequency (prevalence in %) or median (interquartile range (25th–75th percentile), values separated by comma). Statistical analyses were performed using negative binomial regression (PACU length of stay, duration of hypotension) or multivariable logistic regression (all other analyses). Odds ratios (OR) are reported for logistic regression analyses, incidence rate ratios (IRR) for negative binomial regression analyses
MAP Mean Arterial Pressure; PACU Post Anesthesia Care Unit; PACU-OpResc intravenous opioid rescue analgesia in the postanesthesia care unit; PONV Post-Operative Nausea and vomiting