Table 2.
Effects of insulin and intralipid infusion in control and PCOS subjects before exercise
| Study Design ➔ | Saline Study • Saline: 0 to 5 H • Insulin and glucose: 3 to 5 H |
Intralipid Study • Intralipid: 0 to 5 H • Insulin and glucose: 3 to 5 H |
|||
|---|---|---|---|---|---|
| CTRPs & GDFs | Time (H) | Control (N = 9) |
PCOS (N = 10) |
Control (N = 9) |
PCOS (N = 10) |
| CTRP2 (ng/mL) | 0 | 1.6 ± 0.4 | 1.5 ± 0.5 | 1.9 ± 0.6 | 1.7 ± 0.7 |
| 3H | 1.6 ± 0.6 | 1.8 ± 0.7 | 4.9 ± 2.4a,d | 3.9 ± 2.2a,d | |
| 5H | 1.9 ± 1.0 | 2.1 ± 1.0 | 4.7 ± 1.7a,d | 4.4 ± 1.9a,d | |
| CTRP9 (ng/mL) | 0 | 62.8 ± 19.2 | 56.6 ± 19.1 | 62.9 ± 23.1 | 56.9 ± 23.1 |
| 3H | 65.3 ± 18.9 | 58.4 ± 15.4 | 69.4 ± 23.2 | 65.4 ± 27.2 | |
| 5H | 70.3 ± 24.9 | 57.3 ± 15.7 | 57.8 ± 22.8b | 53.8 ± 30.9b | |
| GDF8 (ng/mL) | 0 | 2.3 ± 1.1 | 3.1 ± 1.8 | 2.8 ± 1.1 | 2.8 ± 1.2 |
| 3H | 2.0 ± 0.8 | 2.7 ± 1.2 | 2.8 ± 1.0 | 2.6 ± 1.1 | |
| 5H | 1.7 ± 0.7a | 2.3 ± 0.9a | 2.4 ± 0.7d | 2.6 ± 1.0 | |
| GDF15 (ng/mL) | 0 | 0.5 ± 0.2 | 0.6 ± 0.2 | 0.7 ± 0.4 | 0.7 ± 0.3 |
| 3H | 0.8 ± 0.5 | 0.7 ± 0.2 | 0.7 ± 0.4 | 0.7 ± 0.2 | |
| 5H | 0.9 ± 0.6a | 0.8 ± 0.2 | 1.2 ± 1.0 | 1.2 ± 0.8b | |
The data are represented as Mean ± SD
Statistical significance (P < 0.05) is shown in the table with superscripts a, b, c and d
a compares 3H or 5H versus 0; b compares 5H versus 3H; c compares PCOS values versus respective control values; and d compares intralipid values versus respective saline values
CTRPs C1Q/TNF related proteins, GDFs Growth differentiation factors
a, b and d: Student’s paired t-test; c: Two-way ANOVA