Table 4.
Effects of insulin and intralipid infusion in control and PCOS subjects after exercise
| Study Design ➔ | Saline Study • Saline: 0 to 5 H • Insulin and glucose: 3 to 5 H |
Intralipid Study • Intralipid: 0 to 5 H • Insulin and glucose: 3 to 5 H |
|||
|---|---|---|---|---|---|
| Clinical Variables | Time (H) | Control (N = 9) |
PCOS (N = 10) |
Control (N = 9) |
PCOS (N = 10) |
| CTRP2 (ng/mL) | 0 | 1.7 ± 0.6 | 1.7 ± 0.6 | 1.7 ± 0.5 | 1.6 ± 0.6 |
| 3H | 1.7 ± 0.6 | 1.8 ± 0.7 | 3.2 ± 1.4a,d | 3.4 ± 1.2a,d | |
| 5H | 2.1 ± 1.4 | 2.3 ± 0.8 | 3.6 ± 1.6a | 3.5 ± 1.1a,d | |
| CTRP9 (ng/mL) | 0 | 59.9 ± 37.4 | 54.3 ± 23.9 | 66.1 ± 27.7 | 65.8 ± 17.5 |
| 3H | 80.4 ± 49.8 | 70.1 ± 17.6 | 67.7 ± 34.8 | 67.5 ± 22.3 | |
| 5H | 74.5 ± 49.2 | 69.7 ± 24.4 | 60.1 ± 44.9 | 59.5 ± 14.9 | |
| GDF8 (ng/mL) | 0 | 1.3 ± 0.4 | 1.6 ± 0.6 | 1.6 ± 0.9 | 1.6 ± 0.9 |
| 3H | 1.2 ± 0.3 | 1.5 ± 0.4 | 2.5 ± 0.8a,d | 2.6 ± 1.0a,d | |
| 5H | 1.0 ± 0.3a,b | 1.3 ± 0.5 | 2.1 ± 0.9d | 2.2 ± 1.1a,b,d | |
| GDF15 (ng/mL) | 0 | 0.5 ± 0.3 | 0.6 ± 0.2 | 0.7 ± 0.2 | 0.7 ± 0.2 |
| 3H | 0.3 ± 0.2a | 0.6 ± 0.5 | 0.5 ± 0.4 | 0.5 ± 0.4 | |
| 5H | 0.5 ± 0.3b | 0.9 ± 0.4b,c | 0.9 ± 0.9 | 1.1 ± 0.9b | |
The data are represented as Mean ± SD
Statistical significance (P < 0.05) is shown in the table with superscripts a, b, c and d
a compares 3H or 5H versus 0; b compares 5H versus 3H; c compares PCOS values versus respective control values at different time point; and d compares intralipid values versus respective saline values
CTRPs C1Q/TNF related proteins, GDFs Growth differentiation factors
a, b and d: Student’s paired t-test, c: Two-way ANOVA