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. 2021 Apr 12:1–14. doi: 10.1080/00498254.2021.1909782

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Figure 1. — A schematic representation of the pharmacokinetic model used for the simulations. This model was obtained from the study of Thomas et al. (1989). Colchicine is distributed in two compartments, the central and the peripheral compartment. Key: Vc, volume of distribution of the central compartment; Clr, first-order renal clearance from the central compartment; Clnr, first-order non-renal clearance from the central compartment; k12, first-order inter-compartmental transfer constant from the central to the peripheral compartment; k21, first-order inter-compartmental transfer constant from the peripheral to the central compartment.