Figure A1.

Mean simulated plasma colchicine concentrations (μg/l) versus time (h) of patients with normal clearance, mild renal impairment, moderate renal impairment, severe renal impairment, 30% impaired total clearance, 50% impaired total clearance, 70% impaired total clearance receiving dosing schemes A: 1 mg once daily, B: 0.5 mg once daily, C: 0.5 mg twice daily, D: Loading dose of 1.5 mg, followed by 0.5 mg after 2 h and then 0.5 twice daily for 14 days, E: 0.5 mg twice daily for the first 3 days and then 0.5 once daily for 27 days, F : Loading dose of 1.5 mg, followed by 0.5 mg after 1 h and then 0.5 twice daily. Upper line: 3 μg/l, plasma concentration that elicits toxic effects. Lower line: 0.5 μg/l, minimum effective plasma concentration.