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. 2021 Apr 19;13(5):451–457. doi: 10.1038/s41557-021-00662-w

Fig. 2. Schematic of the development of automated SPS-flow synthesis of APIs and derivatives.

Fig. 2

a, Merging SPS with flow synthesis for automated API synthesis. b, The workflow for the development of a CRF for the automated synthesis of APIs (from solution-batch synthesis, via SPS-batch synthesis, to automated SPS-flow synthesis). The established CRF allows for digital storage of the preparation of the pharmaceutical molecule, and can be applied for derivatization of the lead compound through both early and late-stage diversification in a push-button fashion. BPR, back-pressure regulator.