. Author manuscript; available in PMC: 2022 Jan 1.

Published in final edited form as: J Alzheimers Dis. 2021;79(3):1041–1054. doi: 10.3233/JAD-200176

Table 2.

Top ten metabolite*age interactions on executive function

Metabolite	Super pathway	Sub pathway	p
Cysteine S-sulfate	Amino acid	Methionine, cysteine, SAM and taurine metabolism	5.2e-05
X – 13866 (C₁₂H₁₈O₅)	Partially characterized molecules	Partially characterized molecules	7.3e-05
X – 12839 (fatty acid 8 : 1 acyl glutamine conjugate)	Partially characterized molecules	Partially characterized molecules	7.9e-05
Erucate (22 : 1n9)	Lipid	Long chain fatty acid	1.5e-04
Glycine conjugate of C₁₀H₁₂O₂	Partially characterized molecules	Partially characterized molecules	1.8e-04
X – 18887	Unknown	Unknown	2.2e-04
X – 12104 (fatty acid 6 : 1 acyl glutamine conjugate)	Partially characterized molecules	Partially characterized molecules	5.4e-04
Dihomo-linolenoyl-choline	Lipid	Fatty acid metabolism (Acyl choline)	5.4e-04
N6-acetyllysine	Amino acid	Lysine metabolism	5.5e-04
Heptenedioate (C7 : 1-DC)	Lipid	Fatty acid, Dicarboxylate	5.9e-04

p-values are unadjusted. Bold p-values are statistically significant using a Benjamini-Hochberg adjustment for multiple comparisons.