Table 1.
Demographic and clinical characteristics and laboratory findings.
| Patient 1 | Patient 2 | |
|---|---|---|
| Demographic characteristics | ||
| Age (years) | 59 | 50 |
| Sex | Male | Male |
| Initial findings | ||
| Medical history | Hypertension | None |
| Symptoms at disease onset | Fever, Dyspnea | Fever, Dyspnea |
| Treatment before admission to ICU | Antibiotic, hydroxychloroquine, LMWH | Antibiotic, hydroxychloroquine, LMWH |
| Laboratory findings on admission | ||
| Hemoglobin (g/dl) (normal value 13.2–17.3) | 13.5 | 12.3 |
| White cells (cells/uL) (normal value 4000–11,000) | 8400 | 11,600 |
| Total neutrophils (cells/uL) (normal value 1500–8000) | 8000 | 9900 |
| Total lymphocytes (cells/uL) (normal value 1000–4800) | 200 | 600 |
| Platelet count (cells/uL) (normal value 150,000–450,000) | 243,000 | 324,000 |
| Nadir platelet count (cells/uL) | 107,000 | 28,000 |
| AntiPF4 antibodies OD units (normal value <0.4) | 0.81 | 2.13 |
| % inhibition of OD reactivity by high heparin (normal value <50) | 88 | 87 |
| Creatinine (umol/L) (normal value 60–110) | 84 | 76.04 |
| EGFR (ml/min/1.73 m2) (normal value >90) | 88 | 101 |
| Total bilirubin (umol/L) (normal value 1.71–20.5) | 22.57 | 26.68 |
| Alanine aminotransferase (ukat/L) (normal value 0–0.58) | 0.52 | 1.17 |
| Aspartate aminotransferase (ukat/L) (normal value 0–0.58) | 0.68 | 1.03 |
| Hs-Troponin I (ng/ml) (normal value <0.034) | 0.033 | 0.027 |
| Lactate dehydrogenase (ukat/L) (normal value 2.34–4.68) | 10.49 | 7.58 |
| INR (normal value <1.1) | 1.36 | 1.16 |
| aPTT (s) (normal value 30–40) | 28.3 | 22 |
| Fibrinogen (mg/dl) (normal value 170–410) | 580 | 462 |
| D-Dimer (mg/l) (normal value <500) | 4114 | 3991 |
| Antithrombin (%) (normal value 80–120%) | 72.1 | 89.2 |
| C-reactive protein (ug/l) (normal value 68–8200) | 290,900 | 72,600 |
| Procalcitonin (ng/ml) (normal value <0,5) | 7.21 | 3.77 |
| Platelet count 1 week after heparin interruption (cells/uL) | 258,000 | 210,000 |
| Scores | ||
| 4T score | 5 | 4 |
| HEP score | 6 | 3 |
| Thrombotic complications | ||
| Site of thrombosis | Bilateral pulmonary embolism | None |
CAD denotes coronary artery disease, ICU intensive care unit, LMWH low molecular weight heparin, PF4 platelet factor 4, EGFR estimated glomerular filtration rate, INR international normalized ratio, aPTT activated partial thromboplastin time, ND not determined, and HEP heparin-induced thrombocytopenia expert probability, OD optical density.