Intraocular pressure (IOP)–related differences at five-minute intervals during the first hour of nocturnal acrophase, both with and without continuous positive airway pressure (CPAP) therapy. Note: statistically significant differences (P < 0.05) are indicated with an asterisk in the graph. It was observed that the increase in IOP during the initiation of the nocturnal acrophase was faster with than without CPAP, with significant differences at 20, 25, 30, and 55 minutes.