Figure 4.

L-DOPA treatment protects visual function in diabetic rats. At the 3-week time point, DM rats showed significant reductions in SF thresholds (three-way repeated ANOVA interaction effect, (3, 85) = 10.72, P < 0.0001; Holm-Sidak post hoc, P < 0.0001). DM DOPA rats showed significant protection against further losses in SF thresholds compared with DM vehicle rats at both 6 and 10 weeks (Holm–Sidak post hoc, P < 0.0001). The green dotted line represents the start of daily L-DOPA treatment for DOPA rats, and the shaded green region indicates daily L-DOPA treatment for rats in DM DOPA and control DOPA groups. ***P < 0.001; ****P < 0.0001