Table II.

Significantly downregulated mRNAs following the overexpression of IRF1 according to RNA sequencing.

ID	Base mean	Base mean control sample NC	Base mean case sample Ad-IRF1	Fold change	log2 fold change	P-value	Adjusted P-value	Gene
CYR61	286.7657	445.3502	128.1812	0.2878	−1.7968	5.70×10−39	1.79×10−35	Down
CTGF	226.0636	362.1031	90.0241	0.2486	−2.0080	1.09×10−38	2.86×10−35	Down
SLC2A3	411.6516	618.3295	204.9737	0.3315	−1.5929	1.27×10−37	2.74×10−34	Down
GPRC5A	861.9170	1180.5053	543.3287	0.4603	−1.1195	1.39×10−37	2.74×10−34	Down
C1orf116	432.2862	629.9506	234.6219	0.3724	−1.4249	3.39×10−36	5.92×10−33	Down
TINAGL1	717.7809	986.1473	449.4144	0.4557	−1.1338	3.75×10−34	5.35×10−31	Down
AMOTL2	449.3289	700.5839	198.0739	0.2827	−1.8225	2.93×10−29	2.70×10−26	Down
KRT4	454.6213	609.3405	299.9020	0.4922	−1.0228	8.74×10−21	3.35×10−18	Down
ANKRD1	44.2735	81.4814	7.0655	0.0867	−3.5276	3.36×10−20	1.15×10−17	Down
AJUBA	657.5500	909.5501	405.5498	0.4459	−1.1653	1.63×10−19	5.03×10−17	Down
CLIC5	348.2467	471.4531	225.0403	0.4773	−1.0669	2.02×10−18	5.38×10−16	Down
SAMD4A	146.1898	214.0379	78.3416	0.3660	−1.4500	1.41×10−15	2.27×10−13	Down
TAF13	106.3080	155.0966	57.5194	0.3709	−1.4310	9.57×10−12	6.90×10−10	Down
ZNF566	209.2546	290.5804	127.9288	0.4403	−1.1836	1.15×10−11	8.20×10−10	Down
CITED2	192.1906	259.8504	124.5308	0.4792	−1.0612	1.96×10−11	1.35×10−9	Down
EMP1	303.1375	421.9202	184.3549	0.4369	−1.1945	2.02×10−11	1.38×10−9	Down
GALNT3	306.3284	426.9941	185.6626	0.4348	−1.2015	4.12×10−11	2.55×10−9	Down
PAQR3	161.8251	220.2059	103.4443	0.4698	−1.0900	1.47×10−10	8.01×10−9	Down
ZNF540	118.3167	167.1335	69.4998	0.4158	−1.2659	1.80×10−10	9.46×10−9	Down
GRHL3	87.9749	134.5827	41.3672	0.3074	−1.7019	4.25×10−10	2.05×10−8	Down

Ad, adenovirus expression vector; IRF1, interferon regulatory factor 1; NC, negative control.