Appendix 2. Electrocardiographic alterations found in patients with early-onset condition, by type of leukemia and stage of evaluation.

	At diagnosis (n= 38)	At the end of induction (n = 37) DAA 100 mg / m2.	End of intensification (n = 27) DAA 150 mg / m2.	At the end of reinduction (n = 17) DAA270 mg / m2.
High risk acute lymphoblastic leukemia
Electrocardiographic Alterations
Pulse generation	2	1	1	0
Intraventricular conduction	0	2	2	0
Repolarization disorders	2	0	0	3
Arrhythmias	0	S1, Q3, T3 AV block ^ grade 1	0	0
	At diagnosis (n= 42)	At the end of induction (n = 41) DAA 100 mg / m2	At end of early intensification (n = 40)	At the end of reinduction (n = 36) DAA: 120 mg/m2
Intermediate risk acute lymphoblastic leukemia
Electrocardiographic Alterations
Pulse generation	2	2	1	0
Intraventricular conduction	2	0	3	4
Repolarization disorders	1	0	3	3
Arrhythmias	0	2 arrhythmias: low atrial rhythm	1 block AV grade 1 1 without data	1 right branch block 1 TSV * 1 repolarization disorder
	At diagnosis (n= 14)	At the end of induction (n = 14) DAA 120 mg / m2	At the end of intensification (n = 13)	At the end of reinduction (n = 13) DAA120 mg / m2
Standard risk acute lymphoblastic leukemia
Electrocardiographic Alterations
Pulse generation	1	0	0	0
Intraventricular conduction	0	0	0	0
Repolarization disorders	0	1	0	0
Arrhythmias	0	1 without data	1 without data	0
	At diagnosis (n= 18)	At the end 7x3 (1) DAA 149 mg / m2.	At the end of cycle 7x3 (2) DAA 149 mg / m2.	At the end of treatment DAA 298 mg / m2.
Acute myeloid leukemia
Electrocardiographic Alterations
Pulse generation	0	1	2	0
Repolarization disorders	1	2	0	3
Arrhythmias	0	1 patient with right bundle branch block	1 patient with low atrial rhythm	1 patient with low atrial rhythm

Source: table of own creation. ÂV: atrioventricular, SVT *: supraventricular tachycardia. DAA: cumulative dose of anthracyclines.