Table 2. Genetic variants in Peruvian pregnant women with preeclampsia and controls.
| Gene | Genotypes and alleles | Preeclampsia | Controls | OR | 95% CI | p a |
|---|---|---|---|---|---|---|
| n (%) | n (%) | |||||
| VEGF +936 C/T | CC | 19 (42.2) | 19 (38.8) | Reference | 0.062 | |
| CT | 12 (26.7) | 23 (46.9) | 0.523 | 0.203-1.341 | ||
| TT | 14 (31.1) | 7 (14.3) | 2.000 | 0.661-6.056 | ||
| C | 50 (55.6) | 61 (62.2) | Reference | 0.434 | ||
| T | 40 (44.4) | 37 (37.8) | 1.319 | 0.736-2.362 | ||
| GG | 7 (17.0) | 15 (33.3) | Reference | 0.256 | ||
| +405 G/C | GC | 27 (69.2) | 24 (53.4) | 2.411 | 0.842-6.904 | |
| CC | 5 (12.8) | 6 (13.3) | 1.786 | 0.403-7.906 | ||
| G | 41 (52.6) | 54 (60.0) | Reference | 0.356 | ||
| C | 37 (47.4) | 36 (40.0) | 1.354 | 0.734-2.498 | ||
| CC | 4 (20.0) | 13 (33.3) | Reference | 0.004 | ||
| CG | 7 (35.0) | 23 (59.0) | 0.989 | 0.243-4.028 | ||
| IL6 -174 G/C | GG | 9 (45.0) | 3 (7.7) | 9.750 | 1.744- 54.525 | |
| C | 15 (37.5) | 49 (62.8) | Reference | 0.011 | ||
| G | 25 (62.5) | 29 (37.2) | 2.816 | 1.281-6.191 | ||
| CC | 30 (61.2) | 29 (58.0) | Reference | 0.946 | ||
| CT | 18 (36.7) | 20 (40.0) | 0.870 | 0.385-1.968 | ||
| IL1B -511 C/T | TT | 1 (2.1) | 1 (2.0) | 0.967 | 0.058-16.192 | |
| C | 78 (79.6) | 78 (78.0) | Reference | 0.863 | ||
| T | 20 (20.4) | 22 (22.0) | 0.909 | 0.460-1.798 | ||
| GG | 13 (27.7) | 12 (26.7) | Reference | 0.832 | ||
| GA | 23 (48.9) | 20 (44.4) | 1.062 | 0.396-2.849 | ||
| APOA1 -75 G/A | AA | 11 (23.4) | 13 (28.9) | 0.781 | 0.254-2.400 | |
| G | 49 (52.1) | 44 (48.9) | Reference | 0.768 | ||
| A | 45 (47.9) | 46 (51.1) | 0.878 | 0.493-1.566 | ||
| X-X- (CC) | 28 (59.6) | 25 (55.6) | Reference | 0.676 | ||
| APOB100 | X- X+ (CT) | 12 (25.5) | 15 (33.3) | 0.714 | 0.282-1.813 | |
| 2488 C/T (XbaI) | X+X+ (TT) | 7 (14.9) | 5 (11.1) | 1.250 | 0.352-4.442 | |
| X- | 68 (72.3) | 65 (72.2) | Reference | 0.883 | ||
| X+ | 26 (27.7) | 25 (27.8) | 0.994 | 0.521-1.896 |
The genotype frequencies of the +936 C/T and +405 G/T variants of the VEGF gene and of the 2488 C/T (XbaI) polymorphism of the APOB100 gene in women with preeclampsia were in Hardy-Weinberg disequilibrium. a According to chi-square test or Fisher’s exact test.