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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2020 Dec 11;1868(3):118929. doi: 10.1016/j.bbamcr.2020.118929

Figure 5: Cdh1 and APC1 interaction increases on TBK1 inhibition.

Figure 5:

Cells were synchronized at G1/S and released for 9 hours (R9) and treated with TBK1 inhibitor MRT67307 for 7 hours, starting 2 hours after release. (A-B) Confocal images of PLA show an increased association of Cdh1 and APC1 in A549 (A) and H460 (B) cells after TBK1 inhibition. Red dots represent foci of interaction of Cdh1 with APC1. DAPI is shown in blue and phalloidin in green. Plots represent quantification of interaction from two independent experiments. A minimum of 100 cells were considered for each quantification. A two-tailed t-test was done for significance. p≤ 0.05 was considered significant. Error bars represent mean ± S.D.