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. 2020 Jul 23;41(5):958–974. doi: 10.1177/0271678X20942613

Figure 6.

Figure 6.

Scriptaid alleviates white matter injury after ICH. (a–c) Double immunofluorescence staining for NF200 and MBP in the ipsilateral striatum and corpus callosum 35 days after ICH (scale bar = 100 µm) and the fold decrease of MBP and NF200 in the striatum and corpus callosum demonstrated the degree of WMI 35 days after ICH. (d) Representative images of myelin sheath damage in sham, vehicle and scriptaid groups 35 days after ICH. (e) Quantification of the g-ratio (the ratio of axonal diameter to overall diameter of the axon plus myelin) and axon density in sham, vehicle and scriptaid groups 35 days after ICH. (f) Representative traces of the evoked CAPs in the CC (stimulus, 0.175 mA; 0.48 mm lateral to the stimulating electrode) 35 days after ICH. (g) Signal conduction along nerve fibers, as measured by the amplitude of the N1 component of the CAPs in response to increasing stimulus strength (0.0–0.20 mA). (h) N1 amplitude in response to a 0.175 mA stimulus 35 days after ICH. n = 5–9/group. *p≤ 0.05, **p≤ 0.01. All data are presented as mean ± SD.