Figure 7.

Scriptaid modulates microglia/macrophage polarization and reduces neuroinflammation after ICH. (a) Double immunostaining of the M1 marker CD16/32 and Iba1 marker in activated microglia in the ipsilateral basal ganglia and quantification of CD16/32⁺ cells one, three, and seven days after ICH. (b) Double immunostaining of the M2 marker CD206 and Iba1 marker for activated microglia in the ipsilateral basal ganglia and quantification of CD206⁺ cells one, three, and seven days after ICH. (Scale bar=100 µm). (c) RT-PCR demonstrated a decrease in proinflammatory-cytokine genes in the scriptaid-treated group. n = 5–6/group. *p≤0.05, **p≤0.01. All data are presented as mean ± SD.