Table 1.
Changes in protein expression levels of transporters in brain capillary fraction isolated from Wt and Glut1+/− mouse.
| Protein name | Uniprot ID | Fold change (Glut1+/−/Wt) | p-value |
|---|---|---|---|
| ABC transporter | |||
| Abcb1a (Mdr1a/P-gp) | P21447 | 1.04 | 3.64.E-01 |
| Abcc4 (Mrp4) | E9Q236 | 1.04 | 7.61.E-01 |
| Abcc9 | P70170 | 0.875 | 1.85.E-01 |
| Abcg2 (Bcrp) | Q7TMS5 | 1.04 | 4.06.E-01 |
| SLC transporter | |||
| Slc2a1 (Glut1) | P17809 | 0.611 | 5.71.E-02 |
| Slc3a2 | P10852 | 1.04 | 6.32.E-01 |
| Slc6a20a | Q8VDB9 | 1.05 | 6.27.E-01 |
| Slc7a1 | Q09143 | 1.15 | 7.31.E-01 |
| Slc7a5 (Lat1) | Q9Z127 | 1.10 | 5.24.E-01 |
| Slc9a3r2 | Q9JHL1 | 1.24 | 1.12.E-01 |
| Slc16a1 (Mct1) | P53986 | 1.05 | 7.91.E-01 |
| Slc25a5 | P51881 | 1.10 | 2.29.E-01 |
| Slc25a20 | Q9Z2Z6 | 1.00 | 9.99.E-01 |
| Slc25a24 | Q8BMD8 | 1.08 | 2.56.E-01 |
| Slc30a1 | Q60738 | 1.10 | 3.59.E-01 |
| SLCO transporter | |||
| Slco1a4 | Q9EP96 | 0.918 | 4.51.E-01 |
| Slco1c1 | Q9ERB5 | 1.17 | 4.00.E-01 |
| Other transporter | |||
| Mfsd2a | Q9DA75 | 1.14 | 3.14.E-01 |
| Receptor | |||
| Lrp1 | Q91ZX7 | 0.952 | 3.96.E-01 |
| Tfr1 | Q62351 | 1.12 | 4.12.E-01 |
| Tight junction protein | |||
| Claudin-5 | O54942 | 0.943 | 6.17.E-01 |
Note: Each transporter was extracted from the brain capillary endothelial cell (BCEC) selective protein [(expression levels at most highly expressed cell types/expression levels at secondary highly expressed cell types) extracted from the mouse brain RNA-sequencing database is over 1.0-fold].