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. 2020 Jul 15;41(5):1145–1161. doi: 10.1177/0271678X20934071

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Preictal and ictal changes in CBF and arteriole diameter. (a) Schematic of changes in CBF and vessel diameter during the pre-injection, preictal and ictal periods. To estimate preictal changes (%), each preictal level was normalized by the average pre-injection level. To estimate ictal change, the ictal level was averaged during the full ictal period, and this value was then normalized with the preceding preictal level. (b) Preictal (−27.98 ± 16.18%) and ictal (69.00 ± 52.47%) CBF changes (total number of seizures = 42, n = 5, mean ± SD, ***p < 0.001 by Wilcoxon signed-rank test). (c) Relationship of the preictal CBF change with the ictal CBF change (total number of seizures = 42, n = 5, Spearman’s r=−0.644, ***p < 0.001, R²=0.572). (d) Preictal (−22.71 ± 13.01%) and ictal (18.47 ± 11.65%) arteriole diameter changes (total number of seizures = 53, n = 8, mean±SD, ***p < 0.001 by Wilcoxon signed-rank test). (e) Relationship of the preictal arteriole change with the ictal arteriole change (total number of seizures n = 53, n = 8, Spearman’s r=−0.848, ***p < 0.001, R²=0.746).