Table 4.
Regions of homozygosity having shared haplotypes that are over-represented in schizophrenia cases.
| Major Haplotype | Gene | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chromosome | Position | Band | Size (kilobases) | SNP count | Case : Control | N | Case : Control | Symbol | Name |
| 1 | 89,116,300–89,286,673 | 1p22.2 | 170.4 | 11 | 9:0 | 3 | 7:0 | PRKN2a | Protein kinase N2 |
| 1 | 89,530,860–89,721,862 | 1p22.2 | 191 | 14 | 9:0 | 5 | 5:0 | GBP1b; GBP2; GBP4; GBP7 | Guanylate binding proteins |
| 14 | 30,070,659–30,290,431 | 14q12 | 219.8 | 19 | 9:0 | 3 | 7:0 | PRKD1c | Protein kinase D1 |
| 14 | 30,991,559–31,172,582 | 14q12 | 181 | 14 | 9:0 | 4 | 6:0 | G2E3 SCFD1d | G2/M Phase-specific E3 Ubiquitin Ligase SEC1 Family Domain Containing 1 |
| 1 | 146,660,395–146,736,137 | 1q21.1 | 75.7 | 11 | 7:0 | 4 | 4:0 | FMO5e CHD1Lf | Flavin Containing Monooxygenase 5 Chromodomain Helicase DNA-binding Protein 1 Like |
| 12 | 8,698,471–8,820,124 | 12p13.31 | 121.7 | 13 | 6:0 | 4 | 3:0 | AICDA MFAP5 | Activation-induced Cytidine Deaminase Microfibrillar-associated Protein 5 |
a
ROH in PRKN2 (NM_006256) contained 16 of 22 exons.
b
ROH in GPB1 (NM_002053) contained one of 11 exons.
c
ROH in PRKD1 (NM_002742) contained 13 of 18 exons.
d
ROH in SCFD1 (NM_016106) contained 16 of 25 exons.
e
ROH in FMO5 (NM_001461) contained 8 of 9 exons.
f
ROH in CHD1L (NM_004284) contained 7 of 23 exons.