KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Bacterial and Virus Strains
Samba Virus	Campos et al., 2014	N/A
Tupanvirus soda lake	Abrahão et al., 2018	N/A
Antarctica virus	Andrade et al., 2018	N/A
Mimivirus strain M4	Boyer et al., 2011	N/A
Biological Samples
Acanthamoeba castellanii	ATCC	ATCC 30010
Chemicals, Peptides, and Recombinant Proteins
Sodium phosphate, dibasic	Sigma-Aldrich	Cat # S9390
Urea	VWR Life Sciences	Cat # 0568
Guanidinium Hydrochloride	Amresco	Cat #0118
Triton X-100	Alfa Aesar	Cat # A16046
Chloroform	EMD	Cat # CX1055
Dimethyl sulfoxide	JT Baker	Cat # 9924-01
Bromelain (from pineapple)	Sigma	Cat # 647-005-00-X
Proteinase K	Roche	Cat #03115879001
DNase I	Roche	Cat # 10104159001
Lysozyme	Amresco	Cat # 0663-5G
712 PYG	ATCC	N/A
Sucrose	JT Baker	Cat # 4072-05
Software and Algorithms
IMOD	Mastronarde and Held, 2017	https://bio3d.colorado.edu/imod/download.html
SerialEM	Mastronarde, 2005	https://bio3d.colorado.edu/SerialEM/download.html
Leginon	Suloway et al., 2005	http://nramm.nysbc.org/downloads/
Amira	ThermoFischer Scientific	https://www.thermofisher.com/us/en/home/industrial/electron-microscopy/electron-microscopy-instruments-workflow-solutions/3d-visualization-analysis-software/amira-life-sciences-biomedical.html
MaxQuant	Cox and Mann, 2008	https://www.maxquant.org/
Andromeda	Cox et al., 2011	http://coxdocs.org/doku.php?id=maxquant:start/
MotionCor2	Zheng et al., 2017	https://msg.ucsf.edu/software
Other
Quantifoil R2/2 Grids	Electron Microscopy Sciences	Cat # Q250-CR2
10 nm Nanogold Fiducial Markers	Aldrich (Millipore)	Cat #741957
VSWP Membrane Filter Discs	Millipore	Cat # VSWP01300
Quantifoil R3.5/1 Grids	Electron Microscopy Sciences	Cat # Q225CR-35
Deposited Data Generated
pH 2 treated sample, Video S3	This work	EMDB: EMD-20747
100°C treated sample, Video S4	This work	EMDB: EMD-20748
pH 2 + 100°C treated sample, Video S6	This work	EMDB: EMD-20746
pH 2 + 100°C treated sample, Video S8	This work	EMDB: EMD-20745