Table 1.
Clinical and pathologic findings
| MN | Mean Age (yr) | Sex (M: F) | Laboratory Findings | Disease Association | Serum Antibody | LM | IF | Complement | IgG Subtype | EM |
|---|---|---|---|---|---|---|---|---|---|---|
| EXT1/EXT2-MN (n=26) | 36 | 1:4 | ANA, dsDNA, SSA, SSB, others | Autoimmune diseases: lupus, MCTD/ | No | Proliferative features may be present | IgG, IgA/IgM | C3, C1q | IgG1 | SE, ME + SU +/− TRI |
| NELL1-MN (n=34) | 63 | 1:1 | Negative | Malignancy | Yes (nonreducing) | Nonproliferative | IgG | C3 | IgG1 | SE, segmental deposits |
| Sema3B-MN (n=11) | 7a; 36b | 6:4 | Negative | Family history | Yes | Nonproliferative | IgG, TBM + | C3 | IgG1 | SE, TRI, TBM + |
| PCDH7-MN (n=10) | 61 | 3:1 | Negative | None | Yes | Nonproliferative | IgG | −/Trace | IgG1, IgG4 | SE |
The numbers in parenthesis represent the total patients with each specific type of MN that were part of the original studies. M, male; F, female; LM, light microscopy; EM, electron microscopy; ANA, anti-nuclear antibody; dsDNA, double-stranded DNA; SSA, anti–Sjögren syndrome–related antigen A; SSB, anti–Sjögren syndrome–related antigen B; MCTD, mixed connective tissue disease; SE, subepithelial; ME, mesangial; SU, subendothelial; TRI, tubuloreticular inclusions.
a
Age in children.
b
Age in young adults.