Table 1.
Baseline characteristics of prevalent RASi users with eGFR <30 ml/min per 1.73 m2 registered in the Swedish Renal Registry during 2007–2017
| Characteristics | eGFR <30 ml/min Per 1.73 m2 Cohort (n=10,254) |
|---|---|
| Median age (IQR), yr | 72 (63–79) |
| Age category, n (%) | |
| <50 | 848 (8.3) |
| 50–59 | 1046 (10.2) |
| 60–69 | 2400 (23.4) |
| 70–79 | 3471 (33.9) |
| ≥80 | 2489 (24.3) |
| Women | 3662 (35.7) |
| Median eGFR (IQR), ml/min per 1.73 m2 | 23 (18–27) |
| eGFR category, n (%) | |
| <15 ml/min per 1.73 m2, n (%) | 1557 (15.2) |
| ≥15 ml/min per 1.73 m2, n (%) | 8697 (84.8) |
| Primary kidney disease, n (%) | |
| Diabetes | 2878 (28.1) |
| Hypertension | 2512 (24.5) |
| GN | 1096 (10.7) |
| Polycystic kidney disease | 574 (5.6) |
| Pyelonephritis | 171 (1.7) |
| Other | 1753 (17.1) |
| Missing | 1270 (12.4) |
| Mean SBP (SD), mm Hg | 139 (22) |
| SBP category, n (%) | |
| <120 | 1430 (13.9) |
| 120–139 | 3670 (35.8) |
| 140–159 | 3224 (31.4) |
| >160 | 1930 (18.8) |
| Mean DBP (SD), mm Hg | 76 (12) |
| DBP category, n (%) | |
| <80 | 5502 (53.7) |
| 80–89 | 3340 (32.6) |
| 90–99 | 1066 (10.4) |
| >100 | 346 (3.4) |
| Median urinary ACR (IQR), mg/mmol | 35 (6–156) |
| ACR category, n (%) | |
| A1 (<3) | 785 (7.7) |
| A2 (3–29) | 1445 (14.1) |
| A3 (30–69) | 614 (6.0) |
| A3 (≥70) | 1835 (17.9) |
| Missing | 5575 (54.4) |
| Mean serum potassium (SD), mmol/La | 4.5 (0.6) |
| Comorbidities, n (%) | |
| Hypertension | 9099 (88.7) |
| Myocardial infarction | 2212 (21.6) |
| Ischemic heart disease | 3390 (33.1) |
| Arrhythmia | 2302 (22.4) |
| Heart failure | 2868 (28.0) |
| Peripheral vascular disease | 1269 (12.4) |
| Cerebrovascular disease | 1620 (15.8) |
| Diabetes mellitus | 5079 (49.5) |
| Chronic obstructive pulmonary disease | 1811 (17.7) |
| Cancer diagnosis in previous 2 yr | 1018 (9.9) |
| Medication, n (%) | |
| Beta blockers | 6928 (67.6) |
| Calcium channel blockers | 6202 (60.5) |
| Diuretics | 8128 (79.3) |
| Statins | 6312 (61.6) |
| Antiplatelets | 4736 (46.2) |
| Potassium binder | 941 (9.2) |
| Calendar year | |
| 2007–2010 | 3431 (33.5) |
| 2011–2013 | 3399 (33.1) |
| 2014–2016 | 3424 (33.4) |
| Hospitalizations | |
| Any hospitalization in previous yr, n (%) | 4325 (42.2) |
| Hyperkalemia hospitalization, n (%) | 415 (4.0) |
| AKI hospitalization in previous yr, n (%) | 481 (4.7) |
SBP, systolic blood pressure; DBP, diastolic blood pressure; ACR, albumin-to-creatinine ratio.
a
Potassium was missing in 37% of individuals.