Table 2.

Univariable and multivariable analyses of risk factors for death-censored allograft loss

Variable		Univariate			Multivariate
	No. of Patients	HR	95% CI	P Value	HR	95% CI	P Value
Clinico-biologic factors
Recipient sex
Female	15	1.00	Reference
Male	29	1.11	(0.39 to 3.17)	0.85			a
Recipient age (per 1-yr increment)	44	1.01	(0.98 to 1.05)	0.49			a
Retransplantation
No	35	1.00	Reference
Yes	8	0.55	(0.15 to 1.96)	0.35			a
Donor type
Living	3	1.00	Reference
Deceased	41	2.15	(0.26 to 17.62)	0.47			a
Donor age (per 1-yr increment)	44	1.00	(0.97 to 1.03)	0.82			a
Number of mismatches A/B/DR
≤3	40	1.00	Reference
>3	4	0.59	(0.13 to 2.61)	0.48			a
Cold-ischemia time per 1-min increment	44	1.00	(0.99 to 1.00)	0.56			a
eGFR at the time of rejectionb (ml/min per 1.73 m2)
≥30	28	1.00	Reference
<30	15	2.45	(0.94 to 6.38)	0.06			a
Proteinuria at the time of rejection (grams/d)
<0.5	25	1.00	Reference
≥0.5	14	5.31	(1.67 to 16.90)	0.002	7.24	(1.51 to 34.60)	0.01
Histologic factorsc
Microvascular inflammationd
2 or 3	26	1.00	Reference
≥4	18	2.92	(1.02 to 8.32)	0.04			NS
Interstitial inflammation and tubulitis
0 or 1	25	1.00	Reference
≥2	19	1.34	(0.50 to 3.55)	0.56			a
Transplant glomerulopathy
0 or 1	38	1.00	Reference
≥2	6	0.98	(0.22 to 4.36)	0.98			a
Endarteritis (vasculitis)
0	39	1.00	Reference
≥1	4	0.40	(0.05 to 3.10)	0.37			a
Arteriosclerosis
0 or 1	32	1.00
≥2	11	2.24	(0.74 to 6.72)	0.14			a
Interstitial fibrosis and tubular atrophy
0 or 1	23	1.00	Reference
≥2	20	2.15	(0.78 to 5.93)	0.13			a
Immunologic factors
MS
No	23	1.00	Reference
Yes	21	3.21	(1.12 to 9.15)	0.02	3.57	(1.04 to 12.18)	0.04
MFI of immuno-dominant DSAe
<6000	38	1.00	Reference
≥6000	6	1.64	(0.36 to 7.36)	0.52			a
MFI of immuno-dominant DSAe (per one-unit increment)	44	1.00	(0.99 to 1.00)	0.75			a
Number of DSA
1	30	1.00	Reference
≥2	14	0.94	(0.30 to 2.89)	0.91			a

HR, hazard ratio; 95% CI, confidence interval; NS, not significant; MFI, mean fluorescence intensity.

^aIndicates the variables that were not tested in the multivariable model.

^bCalculated with the Modification of Diet in Renal Disease formula.

^cBanff scores (0, no significant lesion; 1, mild; 2, moderate; 3, severe).

^dSum of the Banff scores for glomerulitis and capillaritis.

^eMFI of the standard IgG detection assay. Variables at the P level <0.05 in the univariate model were incorporated into the multivariable model.