Figure 5.

Arrangement of myosin heads around a thick filament

(A) Model of a thick filament with surrounding thin filament-bound myosin heads obtained from fitting into the annotated tomogram. The six different colors represent myosin heads bound to the six adjacent thin filaments.

(B) Close-up view of the black inset in (A) showing varying spacings between the tips of adjacent myosin heads.

(C) Different conformations of S2 fragments taken from clearly discernible annotations.

(D–G) Top view of four segments of the thick filament in (A) together with the thin filaments it binds, highlighting heterogeneity of myosin head organization. Each image depicts a segment with a depth of ~40 nm.

See also Figures S2 and S4 and Video S1.