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. 2021 Apr 15;184(8):2135–2150.e13. doi: 10.1016/j.cell.2021.02.047

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© 2021 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Figure S4 — Annotation and fitting of split and double heads of myosin between thin and thick filaments from A-band tomograms, related to Figures 3 and 5

(A) Annotated density of a thin filament including the myosin heads (green), with the annotated density for a myosin double-head highlighted in orange.

(B) Oblique and zoomed-in view of the double-head density and its associated thick filament segmentation (pink).

(C) Same view as in (B) including the fitted thin filament and myosin double-head models from sub-volume averaging.

(D) Annotated density of two thin filaments including the myosin heads (green and light blue), highlighting annotated density corresponding split-head in orange.

(E) Oblique and zoomed-in view of the split-head density and its associated thick filament segmentation.

(F) Same view as in (E) including the fitted thin filament and myosin split-head models. The split-head is composed of two heads in the upper head conformation in order to be fitted into the density.