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. Author manuscript; available in PMC: 2021 Oct 16.
Published in final edited form as: Nat Biomed Eng. 2021 Apr 16;5(4):346–359. doi: 10.1038/s41551-021-00710-3

Fig. 6 ∣. Identification of a combination schedule in mice by optimizing the offset between chemotherapy and radiotherapy.

Fig. 6 ∣

(A) Prediction plots showing the expected fractional volume change over time for the originally identified optimal and suboptimal schedules as well as schedules with the suboptimal and optimal offsets between therapy administrations. (B) Relative fitness across stochastic optimization generations. Each generation consisted of 1024 different schedules being tested with 128 instances of each schedule, creating the required technical replicates to account for model stochasticity. (C) Fractional volume change under different offsets between radiotherapy and chemotherapy. Each schedule is simulated 50 times. Error bars, mean +/− s.d. (D) Survival of tumour-bearing mice from initiation of treatment with i.p. TMZ and daily whole brain irradiation with 2 Gy on 5 consecutive days (TMZ/RT). TMZ was administered 41 min prior to irradiation for the optimum-treated mice (N=12) and 8 hours post-irradiation for the suboptimum-treated mice (N=12).