Table 1. Neutralization of sequence matched and unmatched autologous Env-pseudotyped viruses by serum antibodies obtained from 1PGE-THIVC immunized rabbits.
| Neutralization titer (ID50 values) | ||||
|---|---|---|---|---|
| Env-pseudotyped viruses | Rabbit # 1 | Rabbit # 2 | Rabbit # 3 | Rabbit # 4 |
| PG80v1.eJ19 WT | 2284 | 431 | 104 | 342 |
| PG80v1.eJ19 T332N | 1081 | 245 | <20 | <20 |
| PG80v1.eJ17 | 1505 | 194 | 21 | 169 |
| PG80v1.eJ158 | 1123 | 178 | 20 | 103 |
| PG80v1.eJ7 | 1037 | 141 | 20 | 161 |
| PG80v2.eJ38 | 61 | 26 | <20 | 234 |
ID50 values are reciprocal dilutions that conferred 50% neutralization of Env-pseudotyped viruses in TZM-bl cell neutralization assay. Neutralization assays were done in triplicates and repeated at least two times.