Table 2. Comparison of the rabbit serum autologous neutralization titers induced by different Env SOSIP trimers.

	SOSIP.664 Env trimers
	1PGE-THIVC	BG505	AMC008	AMC009	AMC011	B41
Subtypes	C	A	B	B	B	B
Disease stage	Elite neutralizer; Late stage	Founder virus; Early stage	Elite neutralizer; Early stage	Elite neutralizer; Early stage	Elite neutralizer; Early stage	Founder virus; Early stage
Animal No	Neutralization titers§
1	2284	27	<20	<20	<20	249
2	431	2368	186	<20	<20	965
3	104	<20	46	<20	<50	111
4	342	2274	242	<20	<100	601
5	--	3654	29	<100	<500	<20
References	Current Study	de Taeye et al. [19]	de Taeye et al. [19]	Schorcht A, et al [36]	Schorcht A, et al [36]	de Taeye et al. [19]

§ The neutralization titer refers to the reciprocal dilution (as provided in the table) that conferred 50% neutralization of pseudoviruses expressing autologous envs in TZM-bl cells. The ID₅₀ values for rabbit serum neutralization titers induced by AMC009 and AMC011 SOSIP trimers were extrapolated from Schorcht A, et al. [36].