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. Author manuscript; available in PMC: 2021 Apr 19.
Published in final edited form as: Cell Calcium. 2019 Jan 9;78:56–65. doi: 10.1016/j.ceca.2019.01.003

Fig. 2. Monocyte CRAC channels are modulated during infection.

Fig. 2.

SOCE is induced in monocytes in response to bacterial pathogens. In naïve mice or human blood monocytes, the redox sensitive ORAI1 is the predominant isoform. However, during infection, monocytes upregulate expression of the redox-insensitive isoform ORAI3, lending the CRAC-channel more resistant to ROS-mediated inactivation. This switch is important for calcium entry, ROS production and bacterial killing.