Table 1.
Estrogen, Progesterone, and HER2 Receptor Statuses at Initial Diagnosis of the Primary Tumor and in the Brain Metastasis
| Author | N | ER/PR Positive Cutoff | HER2 Positive Cutoff | ER+ | ER− | PR+ | PR− | HR+ | HR− | HER2+ | HER2− | HR+/HER2+ | HR+/HER2− | HR-/HER2+ | HR-/HER2− |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gaedcke et al., 200715 | 23 | >10% IHC | 3+ overexpression IHC or 2+ with FISH | Initial diagnosis | Initial diagnosis | ||||||||||
| 11 | 12 | 6 | 17 | NA | NA | 14 | 30 | NA | NA | NA | NA | ||||
| Brain metastasis | Brain metastasis | ||||||||||||||
| 29 | 56 | 15 | 70 | NA | NA | 29 | 56 | NA | NA | NA | NA | ||||
| Yonemori et al., 200816 | 24 | >10% IHC | 3+ overexpression IHC or 2+ with FISH | Initial diagnosis | Initial diagnosis | ||||||||||
| 25 | 4 | 27 | 2 | NA | NA | 18 | 11 | NA | NA | NA | NA | ||||
| Brain metastasis | Brain metastasis | ||||||||||||||
| 1 | 19 | 1 | 22 | NA | NA | 7 | 14 | NA | NA | NA | NA | ||||
| Broom et al., 200917 | 100 | >10% IHC | 3+ overexpression IHC or 2+ with FISH | Initial diagnosis | Initial diagnosis | ||||||||||
| 73 | 24 | 60 | 35 | NA | NA | 7 | 41 | NA | NA | NA | NA | ||||
| Brain metastasis | Brain metastasis | ||||||||||||||
| 52 | 12 | 26 | 36 | NA | NA | 6 | 34 | NA | NA | NA | NA | ||||
| Hoefnagel et al., 201018 | 44 | >10% IHC | >6 HER2 copies/ tumor cell nucleus | Initial diagnosis | Initial diagnosis | ||||||||||
| NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | ||||
| Brain metastasis | Brain metastasis | ||||||||||||||
| NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | ||||
| Omoto et al., 201019 | 21 | >10% IHC | >30% IHC | Initial diagnosis | Initial diagnosis | ||||||||||
| 9 | 12 | 6 | 15 | NA | NA | 7 | 14 | NA | NA | NA | NA | ||||
| Brain metastasis | Brain metastasis | ||||||||||||||
| 9 | 12 | 4 | 17 | NA | NA | 9 | 12 | NA | NA | NA | NA | ||||
| Shao et al., 201120 | 18 | >1% of cells stained positive | >30% IHC | Initial diagnosis | Initial diagnosis | ||||||||||
| 10 | 8 | 6 | 12 | NA | NA | 6 | 12 | NA | NA | NA | 6 | ||||
| Brain metastasis | Brain metastasis | ||||||||||||||
| 9 | 9 | 6 | 12 | NA | NA | 7 | 11 | NA | NA | NA | NA | ||||
| Brogi et al., 201121 | 209 | >10% IHC | 3+ overexpression IHC or 2+ with FISH | Initial diagnosis | Initial diagnosis | ||||||||||
| 11 | 43 | 6 | 48 | NA | NA | 25 | 30 | NA | NA | NA | NA | ||||
| Brain metastasis | Brain metastasis | ||||||||||||||
| 4 | 27 | 1 | 30 | NA | NA | 18 | 20 | NA | NA | NA | NA | ||||
| Duchnowska et al., 201222 | 120 | >1% of cells stained positive | 3+ overexpression IHC or 2+ with FISH | Initial diagnosis | Initial diagnosis | ||||||||||
| 51 | 69 | 40 | 78 | NA | NA | 51 | 62 | NA | NA | NA | NA | ||||
| Brain metastasis | Brain metastasis | ||||||||||||||
| 29 | 56 | 18 | 67 | NA | NA | 51 | 51 | NA | NA | NA | NA | ||||
| Bachmann et al., 201323 | 32 | >10% IHC | 3+ overexpression IHC or 2+ with FISH | Initial diagnosis | Initial diagnosis | ||||||||||
| 12 | 12 | 13 | 11 | NA | NA | 11 | 13 | NA | NA | NA | NA | ||||
| Brain metastasis | Brain metastasis | ||||||||||||||
| 5 | 17 | 2 | 20 | NA | NA | 12 | 10 | NA | NA | NA | NA | ||||
| Shen et al., 201524 | 140 | >1% of cells stained positive | 3+ overexpression IHC or 2+ with FISH | Initial diagnosis | Initial diagnosis | ||||||||||
| 58 | 76 | 51 | 82 | NA | NA | 56 | 72 | 26 | 34 | 29 | 37 | ||||
| Brain metastasis | Brain metastasis | ||||||||||||||
| 10 | 15 | 9 | 18 | NA | NA | 16 | 19 | NA | NA | NA | NA | ||||
| Thomson et al., 201625 | 41 | Allred score of >3 | 3+ overexpression IHC or 2+ with FISH | Initial diagnosis | Initial diagnosis | ||||||||||
| 15 | NA | 6 | NA | NA | NA | NA | NA | NA | NA | NA | NA | ||||
| Brain metastasis | Brain metastasis | ||||||||||||||
| 18 | NA | 7 | NA | NA | NA | NA | NA | NA | NA | NA | NA | ||||
| Timmer et al., 201726 | 24 | >1% of cells stained positive | 3+ overexpression IHC or 2+ with FISH | Initial diagnosis | Initial diagnosis | ||||||||||
| 10 | 14 | 10 | 14 | NA | NA | 10 | 14 | NA | NA | NA | 5 | ||||
| Brain metastasis | Brain metastasis | ||||||||||||||
| 3 | 21 | 4 | 20 | NA | NA | 15 | 8 | NA | NA | NA | NA | ||||
| Jung et al., 201827 | 37 | >1% of cells stained positive | 3+ overexpression IHC or 2+ with FISH | Initial diagnosis | Initial diagnosis | ||||||||||
| 16 | 21 | 13 | 24 | NA | NA | 19 | 18 | 3 | 13 | 16 | 5 | ||||
| Brain metastasis | Brain metastasis | ||||||||||||||
| 10 | 9 | 10 | 3 | NA | NA | 10 | 6 | NA | NA | NA | NA | ||||
| Sperduto et al., 202028 | 316 | >1% of cells stained positive | 3+ overexpression IHC or 2+ with FISH | Initial diagnosis | Initial diagnosis | ||||||||||
| 140 | 108 | 54 | 180 | 118 | 120 | 133 | 151 | 68 | 88 | 75 | 85 | ||||
| Brain metastasis | Brain metastasis | ||||||||||||||
| 30 | 38 | 30 | 52 | 40 | 38 | 22 | 10 | 84 | 74 | 71 | 87 | ||||
| Hulsbergen et al., 202029 | 219 | >10% IHC | 3+ overexpression IHC or 2+ with FISH | Initial diagnosis | Initial diagnosis | ||||||||||
| 117 | 102 | 79 | 135 | 114 | NA | 96 | 114 | 53 | 61 | 42 | 53 | ||||
| Brain metastasis | Brain metastasis | ||||||||||||||
| NA | NA | NA | NA | NA | NA | NA | NA | 40 | 47 | 64 | 55 |
BM, brain metastasis; ER, estrogen receptor; FISH, fluorescence in situ hybridization; HER2, human epidermal growth factor receptor type 2; HR, hormonal receptor; IHC, immunohistochemistry; NA, not available; PR, progesterone receptor.