Figure 3.

Plasma and brain DLM concentrations as a function of time (mean ± SEM). P15 DLM levels in plasma (A) and brain (B) after doses of 1, 2, or 4 mg/kg DLM from 2 to 8 h post-treatment. Adult DLM levels in plasma (C) and brain (D) after doses of 2, 8, or 25 mg/kg DLM from 2 to 8 h post-treatment. In plasma for P15 rats (females, males), n = (8, 8) except at 1 mg/kg at 4 h, 2 mg/kg at 6 h, and 4 mg/kg at 2 h, n = (7, 8) and at 4 mg/kg at 8 h, n = (6, 7). In brain for P15 rats (females, males), n = (8, 8) except at 1 mg/kg at 4, 6, and 8 h, 2 mg/kg at 6 h, and 4 mg/kg at 2 h, n = (7, 8), n = (8, 7) for 4 mg/kg at 6 h, and n = (6, 6) at 8 h. In blood for adult rats, n = 8, except at 8 mg/kg at 4 and 8 h, n = 7, and n = 6 for 2 mg/kg at 2 h and 25 mg/kg at 4 h. In brain for adult rats, n = 8, except at 2 mg/kg at 4 and 8 h, 8 mg/kg at 2 and 4 h, and 25 mg/kg at 2 h, n = 7.