Figure 4.

C150S/+ mice exhibit a stepwise progression of defects in disc enclosure leading to the formation of membranous whorls. A–G, Representative TEM images of tannic acid/uranyl acetate-stained retinas of C150S/+ mice at P16. Outer segment structural defects ranged from slightly overgrown open discs to membranous whorls. On occasion, overgrown membrane structures extend laterally across the outer segment giving the appearance of open discs in the middle of the outer segment (E). Scale bars, 0.5 µm.