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. 2021 Jan 8;37(2):270–272. doi: 10.1093/bioinformatics/btaa677

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© The Author(s) 2021. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1. — Statistical testing in Deuteros 2.0. Two statistical tests are offered in Deuteros 2.0: (a) peptide and (b) hybrid significance tests. Statistical models are applied to differential HDX-MS data to identify peptides which show statistically significant changes in deuteration between experimental states. Significant peptides are described as regions exhibiting deprotection or protection according to the direction of the deuteration difference. Data shown represent the XylE Δ(E397Q-WT) dataset from Martens et al. (2018)