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Performance diagnostics of 72-week relative change in PDFF in assessing histologic improvement and resolution of NASH
| Event | Prevalence of event | Cross-validated AUROC (95% CI) | Cutoff criteria | Cutoff (Relative change in PDFF) | Sens | Spec | PPV | NPV |
|---|---|---|---|---|---|---|---|---|
| Histologic improvement | 27% | 0.60 (0.45, 0.75) | Sens = 90% | 23.1% | Fixed | 23% | 30% | 87% |
| Spec = 90% | −57.3% | 10% | Fixed | 29% | 73% | |||
| Youden’s index | −29.8% | 48% | 81% | 48% | 81% |
