Table 3.
Univariable and Multivariable Analyses of Covariable Associated with OS
| Variable | Univariable Analysis | Multivariable Analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Age(y) | ||||||
| <60 v ≤60 | 0.926 | 0.656 to 1.307 | 0.662 | |||
| Sex | ||||||
| Female v male | 0.945 | 0.670 to 1.333 | 0.746 | |||
| Smoking Status | ||||||
| Never v current/former | 0.866 | 0.589 to 1.275 | 0.466 | |||
| EGFR Mutation | ||||||
| Exon 19 v Exon 21 | 0.740 | 0.531 to 1.031 | 0.075 | |||
| Systemic Therapy | ||||||
| Platinum treatment | ||||||
| Yes v no | 0.749 | 0.500 to 1.120 | 0.159 | |||
| First-line EGFR TKIs therapy | ||||||
| Yes v no | 1.132 | 0.808 to 1.587 | 0.468 | |||
| Location of Metastasis | ||||||
| Brain Metastasis | ||||||
| Yes v no | 1.266 | 0.890 to 1.801 | 0.189 | |||
| Bone Metastasis | ||||||
| Yes v no | 1.300 | 0.855 to 1.975 | 0.220 | |||
| The Site of Radiotherapy | ||||||
| Thoracic Radiotherapy | ||||||
| Yes v no | 0.544 | 0.388 to 0.763 | <0.001 | 0.514 | 0.323 to 0.818 | 0.005 |
| Brain Radiotherapy | ||||||
| Yes v no | 1.105 | 0.796 to 1.534 | 0.550 | |||
| Bone Radiotherapy | ||||||
| Yes v no | 1.273 | 0.919 to 1.762 | 0.146 | |||
| Number of Radiotherapy sites | ||||||
| 2–4 v 1 | 0.696 | 0.499 to 0.970 | 0.032 | 1.087 | 0.688 to 1.719 | 0.721 |
Abbreviations: EGFR, epidermal growth factor receptor; TKIs, tyrosine kinase inhibitors.