Table 3.
The Top 20 Core Targets in PPI Network of ZSW in Treating DN
| Gene | Target | Degree |
|---|---|---|
| IL6 | Interleukin-6 | 41 |
| MAPK1 | Mitogen-activated protein kinase 1 | 41 |
| JUN | Transcription factor AP-1 | 40 |
| APP | Amyloid-beta precursor protein | 38 |
| TP53 | Cellular tumor antigen p53 | 38 |
| EGF | Pro-epidermal growth factor | 38 |
| MAPK8 | Mitogen-activated protein kinase 8 | 37 |
| VEGFA | Vascular endothelial growth factor A | 37 |
| TNF | Tumor necrosis factor | 33 |
| MAPK3 | Mitogen-activated protein kinase 3 | 33 |
| EGFR | Epidermal growth factor receptor | 32 |
| PTGS2 | Prostaglandin G/H synthase 2 | 28 |
| IL1B | Interleukin-1 beta | 27 |
| ESR1 | Estrogen receptor | 26 |
| SAA1 | Serum amyloid A-1 protein | 24 |
| F2 | Prothrombin | 22 |
| AR | Androgen receptor | 22 |
| MAPK14 | Mitogen-activated protein kinase 14 | 21 |
| CCL2 | C-C motif chemokine 2 | 20 |
| NOS3 | Nitric oxide synthase, endothelial | 20 |
Note: The top 20 core targets in PPI network of ZSW in treating DN constructed by STRING database were screened via Cytoscape cytoHubba plugin and sorted by degree.