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. 2021 Mar 2;96(9):e1334–e1346. doi: 10.1212/WNL.0000000000011523

Figure 4. Core Network of Altered Connectivity in TLE Includes Bilateral Mesial Temporal Structures and Ipsilateral NBM.

Figure 4

Network-based statistic reveals a central network of nodes and edges that are altered in patients vs controls. This component network was tested at multiple t statistic thresholds, and the network contained 43 nodes and 66 edges at t > 4.2, 35 nodes and 49 edges at t > 4.4, and 24 nodes and 27 edges at t > 4.6. At multiple t statistic thresholds, this network included ipsilateral but not contralateral nucleus basalis of Meynert (NBM), included bilateral hippocampi and amygdalae, but did not include other subcortical arousal nuclei. Network-based statistic is performed at p < 0.01 with family-wise error correction. N = 40 patients with temporal lobe epilepsy (TLE) and 40 matched healthy control participants. A = anterior; C = contralateral; I = ipsilateral; P = posterior.