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. 2021 Feb 16;96(7):e975–e985. doi: 10.1212/WNL.0000000000011416

Figure 2. Associations Between Alzheimer Disease (AD) Biomarker Status and Clinical Impairment.

Figure 2

AD biomarker status according to Clinical Dementia Rating (CDR). Each plot represents individuals grouped according to CDR, with bar colors corresponding to AD biomarker status. Individuals with CDR 0 were the most likely to be AD biomarker–negative (72.3%). Despite lower frequency, 8.1% of cognitively unimpaired individuals were positive for both amyloid- and tau-PET biomarkers. Individuals with a CDR of 0.5 displayed heterogeneous patterns of AD biomarkers, with under 40% being biomarker-negative and under 50% being positive for both amyloid- and tau-PET. Individuals with a CDR of 1 were most likely to be positive for both amyloid- and tau-PET biomarkers (84.2%). Finally, 100% of individuals with AD dementia and a CDR of 2 were positive for both amyloid- and tau-PET biomarkers. A−T− = amyloid-negative/tau-negative (normal AD biomarkers); A+T− = amyloid-positive/tau-negative (AD pathologic change); A−T+ = amyloid-negative/tau-positive (non-AD pathologic change); A+T+ = amyloid-positive/tau positive (biological AD).