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. 2021 Feb 23;96(8):e1227–e1236. doi: 10.1212/WNL.0000000000011467

Figure 1. Age- and Sex-Adjusted MND Incidence, Prevalence, and Mortality and Alzheimer Mortality.

Figure 1

This panel plot shows motor neuron disease (MND) (A) incidence, (B) prevalence, and (C) mortality and (D) Alzheimer mortality in the Netherlands from 1998 through 2017 determined via Poisson regression. Dashed lines indicate the age group with maximum rates. There was a differential effect of age for men and women on incidence (p < 0.01 for interaction term), prevalence, and mortality (both p < 0.001). For example, highest MND prevalence and mortality rates occurred at later ages for men than for women. In contrast, highest Alzheimer mortality rates occurred in the oldest age group (>95 years) for both men and women. This suggests that MND risk is not merely a result of aging. Age- and sex-stratified MND incidence was determined on the basis of data from the Netherlands MND registry. MND prevalence was determined by capture-recapture methodology using data from the Netherlands MND registry and Netherlands Patient Association for Neuromuscular Diseases. MND mortality and Alzheimer mortality were determined from mortality records in the Netherlands Personal Records database.