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. 2021 Apr 14;14:981–992. doi: 10.2147/JPR.S295795

Figure 5.

Figure 5

Influence of TA forms: TA-MS-HP-β-CD, TA-MS-M-β-CD and pure TA, administered orally 60 min before pain tests, on tactile allodynia measured in the von Frey test (A) and thermal hyperalgesia assessed in the hot plate test (B) in a mouse model of migraine pain induced by NTG administration. NTG was injected 60 min before pre-drug measurements of pain sensitivity were collected. Results are shown as mean paw withdrawal force (±SEM) measured in the von Frey test (A), or latency time to pain reaction (±SEM) measured in the hot plate test (B) for n = 6–10. Statistical analysis: repeated measures ANOVA followed by Dunnett’s or Tukey’s post hoc test. Significance vs paw withdrawal threshold or latency to pain reaction before NTG administration: #p < 0.05, ##p < 0.01, ####p < 0.0001; and significance vs pre-drug paw withdrawal threshold or pre-drug latency to pain reaction in the individual group: **p < 0.01, ****p < 0.0001.